HI
I have been using VS2015 for over a year on the Netduino 2+ without a problem. There are posts on here that cover setting it up but this is from my notes.
Install MicroFrameworkSDK.MSI (4.3 SDK-QFE2)
Install netduinosdk.exe (4.3.2 May 2015)
Install VS plugin - right one for the version in use (netmfvs14.vsix)
Update firmware on device using updater
See my post on issues I found and solved here