Hi Chris,
My development environment is VS2012 and NP2-V4.3.2.0. I changed the debug port to COM1 and everything works fine.
I'm trying to build a simple HID device and used "Netduino Virtual Keybord sample" as a starting point.
I created a new NP2 Application in VS2012 and copied the Program.cs code to my new app (and also added Microsoft.SPOT.Hardware.Usb). Everything compiles fine and I can debug the app. When plugging the usb cable I get the "Pressing Key..." string in the debugger window. I opened a Notepad before plugging the cable, but there's no character typing.
Also, inside Windows Device Manager, it doesn't show up under "Keyboards" or "Human Interface Devices" (as one would have expected), but it still shows up as Netduino under "Universal Serial Bus controllers".
I appreciate the help.